Contact CADC Program

Center Information

Center Leadership

  • Carl W. Cotman, PhD
    Director / Principal Investigator

    Carl W. Cotman, PhD is the Founding Director of the UC Irvine Institute for Memory Impairments and Neurological Disorders (formerly the Institute for Brain Aging and Dementia) and the principal investigator for the UC Irvine California Alzheimer's Disease Center.

UCI - Irvine CADC

Web Site

UCI - Irvine CADC


UC Irvine – California Alzheimer’s Disease Center
1100 Gottschalk Medical Plaza
Irvine, CA 92697-4285

Phone Numbers

949-824-2382 (main)

949-824-3049 (fax)

History and Background

The University of California, Irvine (UCI) CADC, established in 1989, operates within the Institute for Memory Impairments and Neurological Disorders located on the UCI main campus. One of the premiere assessment centers in Orange County, the UCI CADC provides specialized diagnostic and treatment services to optimize the cognitive, functional, and behavioral abilities of individuals with Alzheimer’s disease (AD) to improve health care delivery and quality of life for both patients and caregivers. The UCI CADC serves some 326,900 individuals age 65 and older living in Orange County, more than 10% of the county’s total population. The UCI CADC also provides services to individuals living in San Bernadino, Riverside, Southern Los Angeles, and Northern San Diego Counties. As the risk of developing AD increases dramatically with age – to nearly 50% of individuals 85 or older - many of the county’s seniors and their families will unfortunately be affected by this degenerative disorder. Given the large number of Orange County seniors at risk of developing cognitive impairment, the UCI CADC is actively addressing this problem by offering patients and their families access to state-of-the-art diagnostic and treatment services, novel clinical trials, specialized support groups, and educational programs about AD and the related dementias.

Clinical Services

Early identification of cognitive decline and AD is critical so that available treatments, which are most effective before extensive damage to the brain has occurred, can be started, and families can plan for the future, take advantage of available community services, and develop effective coping strategies. UCI CADC clinicians bring state of the art methods to accurately differentiate between normal aging, Mild Cognitive Impairment (MCI), and dementia. The UCI CADC also brings state of the art culturally sensitive methods to assist English, Spanish, Chinese, and Vietnamese speaking individuals and their families through the diagnostic process. In fact, approximately a third of all new patients seeking diagnostic services at the UCI CADC over the past 10 years have been of minority background.

Economic Development and Professional Training

The UCI CADC provides the basic infrastructure to attract new resources into the local economy leveraging the investment of the state by approximately 6-fold or more. These include support from industry for clinical trials, specialized research, student training, and various Federal and private Foundation grants. The UCI CADC translates basic findings from the laboratory into general practice within the broader health care community in a cost-effective fashion. Better behavioral and pharmaceutical interventions must be developed in tandem.

The CADCs have helped to build a vital workforce for the growing needs of the State addressing the current and changing demographic needs in California. This includes the training of physicians, nurses, physician’s assistants, health care professionals, and research investigators. Since 2000, the UCI CADC has trained hundreds of professionals and students through fellowships, residencies, internships, rotations, clerkships, continuing medical education courses, academic classes, lectures, and presentations. Through their training programs the CADCs have shaped the practice of doctors, nurses, psychologists, social workers and other providers who now staff hospitals and clinics throughout the state making daily life more manageable for thousands of people who struggle with the demands of caregiving and the ravages of the AD.

Community Education

The UCI CADC has also educated the lay public, caregivers and families on cognitive decline, prevention strategies, and the management of those afflicted by MCI and AD. The UCI CADC provides many forums on AD education and also serves to integrate education opportunities in the community. The community looks to and depends on the UCI CADC for high quality education.

The limitations in the current health care delivery environment and constrained budgets in both the public and private sectors require solutions that are cost-effective for patients and their families, as well as for businesses. The Centers continue to provide education, provide new opportunities for improving the quality of life of the elderly, and reduce the burden for those with dementia in California.



Referrals from physicians, other healthcare providers, and agencies are welcome. No referral is necessary for a memory assessment. We specialize in the evaluation of memory loss, Alzheimer's disease and related illnesses such as frontotemporal lobe dementia and vascular dementia, and mild cognitive impairment. We have the expertise for complex or unusual cases, and are happy to provide second opinions.


Costs for diagnostic evaluations and professional services may vary on an individual basis. Please contact us for more information. Often, tests performed outside of our CADC may be necessary to complete a diagnostic workup, such as laboratory tests and/or brain scans.


  • Gaby Thai, M.D., Neurologist
  • Malcolm Dick, Ph.D., Neuropsychologist
  • Hyunmie Kim, RN, GNP
  • Beatriz YaZez, R.N.
  • Susan Randhawa, MSW
  • Ken Krisnasmit, Patient Care Coordinator
  • Peter Knaup, Patient Care Coordinator
  • Interns and Residents

Opportunities to Participate in Research

Our Center is part of the UC Irvine Alzheimer’s Disease Research Center. We refer patients to clinical trials evaluating new ways of treating and diagnosing Alzheimer's disease. We also refer patients to studies of aging, and how different factors may protect against or accelerate mental decline in old age. Depending on your eligibility you may be invited to take part in one or more of these studies.